Estradiol benzoate

CAS No. 50-50-0

Estradiol benzoate( β-Estradiol Benzoate | 17β-Estradiol 3-Benzoate | 17β-Oestradiol Benzoate | E2 Benzoate )

Catalog No. M14719 CAS No. 50-50-0

Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG 41 In Stock
1G 48 In Stock

Biological Information

  • Product Name
    Estradiol benzoate
  • Note
    Research use only, not for human use.
  • Brief Description
    Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.
  • Description
    Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.
  • In Vitro
    Cell Cytotoxicity Assay Cell Line:HFFs Concentration:0-500 μM Incubation Time:72 h Result:Inhibited HFFs at the 50% toxicity of 34.11 μM.
  • In Vivo
    Animal Model:Ovx miceDosage:20, 100 or 200 μg/kg Administration:Subcutaneous injection (s.c.)Result:Significantly reversed the lowered uterine weight induced by Ovx.Had no obvious effects on locomotor activity in Ovx mice.Effectively reversed the changes of enlarging the width of synaptic cleft and reducing the thickness of PSD induced by Ovx.Increased the number and density of synaptic vesicles by 4-week replacement with EB (100 μg/kg).
  • Synonyms
    β-Estradiol Benzoate | 17β-Estradiol 3-Benzoate | 17β-Oestradiol Benzoate | E2 Benzoate
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    mERα| hERα
  • Research Area
    Endocrinology
  • Indication
    ——

Chemical Information

  • CAS Number
    50-50-0
  • Formula Weight
    376.49
  • Molecular Formula
    C25H28O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 75 mg/mL (199.2 mM)
  • SMILES
    O=C(OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](O)CC[C@@]4([H])[C@]3([H])CCC2=C1)C5=CC=CC=C5
  • Chemical Name
    [(8R,9S,13S,14S,17S)-17-Hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] benzoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Matthews J, et al. J Steroid Biochem Mol Biol, 2000, 74(4), 223-234.
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